A two-vehicle crash on Route 59 south of Bowles Road in Antioch left multiple people injured Friday evening. | Photo Submitted to Lake and McHenry County Scanner.

Two young children and two adults were hospitalized after a head-on crash in Antioch on Friday. One of the children suffered serious injuries and was flown to the hospital.

The Antioch Police Department and Antioch Fire Department responded around 7:38 p.m. Friday to Route 59 and Bowles Road in Antioch for a report of a two-vehicle crash with injuries.

Antioch Police Department Detective Sergeant Charles Smith told Lake and McHenry County Scanner the crash involved a 2002 Chevrolet Trailblazer and a 2006 Nissan Murano.

A preliminary investigation showed the Chevrolet was traveling northbound on Route 59 south of Bowles Road.

The Chevrolet crossed over into the southbound lanes of traffic for unknown reasons and struck the Nissan head-on, Smith said.

The Chevrolet was driven by a 30-year-old Spring Grove man and his two young children were in the car.

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Smith said the 5-year-old boy and 6-year-old girl were both injured and transported to a local hospital.

One of the kids suffered “significant injuries” and had to be flown to a children’s hospital.

The 30-year-old man driving the Chevrolet and the driver of the Nissan, a 19-year-old Lindenhurst man, were also transported to a local hospital.

Smith said all victims are expected to survive. The driver of the Chevrolet and one of the children have since been released from the hospital.

A family member of the driver of the Nissan said her nephew suffered five breaks in his femur that required surgery.

The cause of the crash remains under investigation, Smith said, adding that Route 59 was closed for several hours Friday as police conducted an investigation at the crash scene.